Endocrine Abstracts

BackgroundThe nonclassical complications of primary hyperparathyroidism (PHPT) can include metabolic syndrome associated with cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia and other disorders are observed in patients with PHPT regardless of the severity of the disease. The aim of this study is to estimate metabolic parameters in patients with PHPT compared to...

Background: Metabolic syndrome may be the nonclassical feature of primary hyperparathyroidism (PHPT) because an increased incidence of various glucose and lipid disorders is often observed in patients with this disease. Earlier we showed PHPT patients had higher serum triglycerides and higher rate of insulin resistance compared to the control group. Dynamics of metabolic parameters after surgery is ambiguous.The aim: of this study was to compare metaboli...

Introduction: There are a lot of conditions associated with human immunodeficiency viri such as lipodystrophy, fat atrophy, insulin resistance, low levels of high-density lipoprotein cholesterol, and hypertriglyceridemia. A diet program combined with exercises can help to treat patients with HIV.Methods: We used an online system for patient education based on video lessons, full of humor, pictures, and cartoons to convey the necessary information on good...

Objective: Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity including hypertension with a prevalence ranging from 40 to 65%. The renin-angiotensin-aldosterone system (RAAS) is a key system in the regulation of sodium/potassium balance, volume homeostasis as well as blood pressure. There is increasing evidence of interactions between calcium and calcium-regulatory hormones with the RAAS. The aim of this study was to investigate the associ...

Objective: Ectopic adrenocorticotropic hormone (ACTH-ectopic) syndrome (EAS) is a rare cause of ACTH-dependent endogenous hypercortisolism. The objective of this study was to analyze the clinical, biochemical, and radiological features, management, and treatment outcome of patients with EAS.Methods: It was a retrospective case-record study of 47 patients with EAS. Clinical, biochemical, and radiological features and response to therapy and survival rate ...

Background: DiGeorge syndrome (DGS) is the rare genetic disorder caused by a 22q11.2 chromosome microdeletion. The main clinical features are associated with defective development of the pharyngeal pouch system and usually include congenital heart disease, hypoplasia of thymus resulting in immune deficiency and hypoparathyroidism. Also DGS patient has characteristic long face with narrow palpebral fissures, broad nasal bridge, micrognathia and small mouth, small dysmorphic ear...

Introduction: We report the clinical presentation of pheochromocytoma with Cushing’s syndrome due to ectopic production of ACTH, and assess the histopathological diagnosis, treatment modality and prognostic factors compared with the literature.Results: Cushing’s Syndrome due to ectopic ACTH production is uncommon and due to pheochromocytoma is extremely rare. We discuss the case of a 50-year-old female who initially presented with vague, non-sp...

The combination of thyroid and parathyroid carcinoma (PC) are extremely rare. We present a case with metastases of both tumors to the lymph nodes of the neck in a woman who received renal replacement therapy with long-term hemodialysis.Case reportIn 1984, when she was 24 years old, the patient began working at a nuclear power plant as a chemical water treatment operator. The total length of service was 25 years. In 2009 (at the age...

Background: Primary hyperparathyroidism (PHPT) can present with not only classic complications like bone and kidney pathology but also with different metabolic disorders and cardiovascular diseases. The prevalence of diabetes mellitus type 2 (DM2) in patients with PHPT is higher than in general population but the mechanism of carbohydrate metabolism alteration in PHPT remains unclear.Aim: The aim of this study is to estimate parameters associated with im...

Objective: Primary hyperparathyroidism (PHPT) is associated with a higher incidence of different cardiovascular diseases (CVD), but the prevalence of CVD in PHPT remains unclear.Aim: To evaluate the prevalence of CVD in PHPT according to the RussianPHPT Registry.Materials and Methods: The Registry includes a database of patients with PHPT available at the Endocrinology Research Centre (Moscow) since 2007, which was transferred to t...